Photo: Bjørn-Kåre Iversen
John Bjarne Hansen
Job description
Forskningsgruppeleder Tromboseforskning (TREC)
Enhetsleder Senter for Tromboseforskning (TREC), Medisinsk klinikk, Universitetssykehuset Nord Norge
Maryam Hosseini,
Kristian Dalsbø Hindberg,
Therese Haugdahl Nøst,
Christian Jonasson,
Kristian Hveem,
John Bjarne Hansen
et al.:
Plasma osteopontin levels are associated with the risk of future incident venous thromboembolism—the Trøndelag Health Study (HUNT)
Journal of Thrombosis and Haemostasis 2025 DOI
Christopher Antoun,
Julia Oto,
Vania Maris Morelli,
Kristian Hveem,
Sigrid Kufaas Brækkan,
Pilar Medina
et al.:
Plasma miR-145-5p Levels and Risk of Future Cancer—Results from the HUNT Study
International Journal of Molecular Sciences 2025 DOI
Asbjørn Lund Onsaker,
Anna Yang Arntzen,
David-Alexandre Trégouët,
Therese Haugdahl Nøst,
Weihong Tang,
Weihua Guan
et al.:
Histo–blood group ABO system transferase plasma levels and risk of future venous thromboembolism: the HUNT study
Blood 2025 DOI
Carl Arne Løchen Arnesen,
Kristian Hveem,
Maiken Elvestad Gabrielsen,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Body height and risk of venous thromboembolism in men vs women
Journal of Thrombosis and Haemostasis 2025 DOI
Christabel Esi Damoah,
Solveig Marie Valderhaug,
Omri Snir,
Kristian Dalsbø Hindberg,
Sigrid Kufaas Brækkan,
Steven P. Grover
et al.:
Elevated Plasma MBL Levels Are Associated With Risk of Future Venous Thromboembolism: HUNT
Arteriosclerosis, Thrombosis and Vascular Biology 2025 DOI
Magnus Edvardsen,
Ellen-Sofie Hansen,
Thor Ueland,
Nadezhda Latysheva,
Pål Aukrust,
Omri Snir
et al.:
Effect of plasma levels of factor VIII according to procoagulant phospholipids on the risk of future venous thromboembolism
Research and Practice in Thrombosis and Haemostasis (RPTH) 2025 DOI
Nikolai Hagensen Eide,
Camilla Langholm,
Fridtjof Balteskard Rinde,
Nick van Es,
Kristian Hveem,
Sigrid Kufaas Brækkan
et al.:
Mortality risk after cancer-related venous thromboembolism has decreased over the last three decades: the HUNT and Tromsø studies
Haematologica 2025 DOI
Oda Leknessund,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Resting Heart Rate and Risk of Incident Venous Thromboembolism: The Tromso Study
Thrombosis and Haemostasis 2025 DOI
Erin Mathiesen Hald,
Maja-Lisa Løchen,
Ellisiv B. Mathiesen,
Kristian Hveem,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
Joint effects of atrial fibrillation and prothrombotic genotypes on the risk of ischemic stroke
Journal of Thrombosis and Haemostasis 2025 DOI
Amandine Bonifay,
Nigel Mackman,
Yohei Hisada,
Ana Teresa Azevedo Sachetto,
Chi Hau,
Elaine Gray
et al.:
Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology
Vania Maris Morelli,
Omri Snir,
Kristian Dalsbø Hindberg,
Kristian Hveem,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: the HUNT study
Carl-Arne Arnesen,
Line Holtet Evensen,
Kristian Hveem,
Maiken Elvestad Gabrielsen,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Proportion of venous thromboembolism attributed to recognized prothrombotic genotypes in men and women
Luuk J.J. Scheres,
Sigrid Kufaas Brækkan,
Judith P.L. Verlaan,
Suzanne C. Cannegieter,
John Bjarne Hansen,
Vania Maris Morelli
:
The fatty liver index and risk of incident venous thromboembolism: the Tromsø Study
Christopher Antoun,
Vårin Eiriksdatter Wikan,
Øyvind Øverli,
Thor Ueland,
Gholamreza Jafari Yeganeh,
Sigrid Kufaas Brækkan
et al.:
Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis
Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 DOI
Eduarda Mazagao Guerreiro,
Sergei G. Kruglik,
Samantha Swamy,
Nadezhda Latysheva,
Bjarne Østerud,
Jean-Michel Guigner
et al.:
Extracellular vesicles from activated platelets possess a phospholipid-rich biomolecular profile and enhance prothrombinase activity
Birgitte Gladsø Tøndel,
Joakim Knutsen Sejrup,
Vania Maris Morelli,
Maja-Lisa Løchen,
Inger Njølstad,
Ellisiv B. Mathiesen
et al.:
Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Study
Daniël Duijzer,
Maria A. de Winter,
Marc Carrier,
Alexander T. Cohen,
John Bjarne Hansen,
Karin A.H. Kaasjager
et al.:
Impact of the VTE-PREDICT calculator on clinicians’ decision making in fictional patients with venous thromboembolism: a randomized controlled trial
Sigrid Kufaas Brækkan,
Asbjørn Lund Onsaker,
Therese Haugdahl Nøst,
Weihong Tang,
Kristian Dalsbø Hindberg,
Vania Maris Morelli
et al.:
The Plasma Proteome and Risk of Future Venous Thromboembolism—Results from the HUNT Study
Oda Leknessund,
Vania Maris Morelli,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Hand grip strength in venous thromboembolism: risk of recurrence and mortality
Monique J.T. Crobach,
Rayna J.S. Anijs,
Sigrid Kufaas Brækkan,
Marianne T. Severinsen,
Jens Hammerstrøm,
Hanne Skille
et al.:
Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study
Maria A. De Winter,
Harry R. Büller,
Marc Carrier,
Alexander T. Cohen,
John Bjarne Hansen,
Karin A. H. Kaasjager
et al.:
Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score
Ellen-Sofie Hansen,
Magnus Edvardsen,
Pål Aukrust,
Thor Ueland,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
et al.:
Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism
Dana Meknas,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study
Samantha Swamy,
Thor Ueland,
John Bjarne Hansen,
Omri Snir,
Sigrid Kufaas Brækkan
:
Plasma levels of P-selectin and future risk of incident venous thromboembolism
Maria A. de Winter,
Alicia Uijl,
Harry R. Büller,
Marc Carrier,
Alexander T. Cohen,
John Bjarne Hansen
et al.:
Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis
Fridtjof Balteskard Rinde,
Camilla Tøvik Jørgensen,
Heidi Hassel Pettersen,
John Bjarne Hansen,
Waleed Ghanima,
Sigrid Kufaas Brækkan
:
Low D-dimer levels at diagnosis of venous thromboembolism are associated with reduced risk of recurrence: data from the TROLL registry
Safak Caglayan,
John Bjarne Hansen,
Omri Snir
:
Optimized workflow to modify microRNA expression in primary human intravascular cells
Casper Jan Elis Ullsten-Wahlund,
Safak Caglayan,
Paulo Czarnewski,
John Bjarne Hansen,
Omri Snir
:
Sustained and intermittent hypoxia differentially modulate primary monocyte immunothrombotic responses to IL-1β stimulation
Tobias Frischmuth,
Birgitte Gladsø Tøndel,
Sigrid Kufaas Brækkan,
John Bjarne Hansen,
Vania Maris Morelli
:
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromso Study
Steven P. Grover,
Omri Snir,
Kristian Dalsbø Hindberg,
Tatianna M. Englebert,
Sigrid Kufaas Brækkan,
Vania Maris Morelli
et al.:
High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
Steven P. Grover,
Tomohiro Kawano,
Jun Wan,
Pansakorn Tanratana,
Zsofia Polai,
Young J. Shim
et al.:
C1 inhibitor deficiency enhances contact pathway–mediated activation of coagulation and venous thrombosis
Espen Waage Skjeflo,
Line Holtet Evensen,
Søren Beck Jensen,
Nadezhda Latysheva,
Annika Elisabet Michelsen,
Thor Ueland
et al.:
Complement factors B, D, C3bBbP and risk of future venous thromboembolism
Magnus Edvardsen,
Ellen-Sofie Hansen,
Thor Ueland,
Pål Aukrust,
Sigrid Kufaas Brækkan,
Vania Maris Morelli
et al.:
Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism
Vårin Eiriksdatter Wikan,
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
Ellen Elisabeth Brodin,
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review
Sigrid Kufaas Brækkan,
John Bjarne Hansen
:
VTE epidemiology and challenges for VTE prevention at the population level: VTE epidemiology
Carolina E. Touw,
Banne Nemeth,
Willem M. Lijfering,
Raymond A. van Adrichem,
line Wilsgård,
Nadezhda Latysheva
et al.:
Effect of lower-leg trauma and knee arthroscopy on procoagulant phospholipid-dependent activity
Joakim Knutsen Sejrup,
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
Maja-Lisa Løchen,
Inger Njølstad,
Ellisiv B. Mathiesen
et al.:
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study
Omri Snir,
line Wilsgård,
Nadezhda Latysheva,
Casper Ullsten-Wahlund,
Sigrid Kufaas Brækkan,
Kristian Dalsbø Hindberg
et al.:
Plasma levels of platelet-derived microvesicles are associated with risk of future venous thromboembolism
Oda Leknessund,
Vania Maris Morelli,
Bjørn Heine Strand,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Hand grip strength and risk of incident venous thromboembolism: The Tromsø study
Christabel Esi Damoah,
Omri Snir,
Kristian Dalsbø Hindberg,
Peter Garred,
Judith K Ludviksen,
Sigrid Kufaas Brækkan
et al.:
High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
Elias Allarai,
Wei-Hsuan Lee,
Stephen Burgess,
Susanna C. Larsson,
Sara Lindstrom,
Lu Wang
et al.:
Genetically predicted cortisol levels and risk of venous thromboembolism
Birgitte Gladsø Tøndel,
Vania Maris Morelli,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review
Line Holtet Evensen,
Carl-Arne Arnesen,
Frits Richard Rosendaal,
Maiken Elvestad Gabrielsen,
Ben Michael Brumpton,
Kristian Hveem
et al.:
The Risk of Venous Thromboembolism Attributed to Established Prothrombotic Genotypes
Paul L. den Exter,
Scott C. Woller,
Helia Robert-Ebadi,
Camila Masias,
Pierre-Emmanuel Morange,
David Castelli
et al.:
Management of bleeding risk in patients who receive anticoagulant therapy for venous thromboembolism: Communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease
Maria A. de Winter,
Alexander T. Cohen,
John Bjarne Hansen,
Karin A.H. Kaasjager,
Ajay K. Kakkar,
Saskia Middeldorp
et al.:
“Risk assessment tools for bleeding in patients with unprovoked venous thromboembolism: an analysis of the PLATO-VTE study”: comment
Journal of Thrombosis and Haemostasis 2025 DOI
Oda Leknessund,
Vania Maris Morelli,
Bjørn Heine Strand,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
:
Corrigendum to ‘Hand grip strength and risk of incident venous thromboembolism: The Tromsø study’: [Res Pract Thromb Haemost. 2022 Nov 4;6/7 e12833] (Research and Practice in Thrombosis and Haemostasis (2022) 6(7), (S2475037922024669), (10.1002/rth2.12833))
Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 DOI
Ellen-Sofie Hansen,
Magnus Edvardsen,
Pål Aukrust,
Thor Ueland,
John Bjarne Hansen,
Sigrid Kufaas Brækkan
et al.:
Galectin-3-binding protein and future venous thromboembolism
Research and Practice in Thrombosis and Haemostasis (RPTH) 2024 DOI
Steven P. Grover,
Linda Sundler Björkman,
Sigrid Kufaas Brækkan,
Bengt Zöller,
John Bjarne Hansen,
Nigel Mackman
:
“C1-inhibitor levels and Venous Thromboembolism: Results from a Mendelian Randomization Study”: comment from Grover et al
Journal of Thrombosis and Haemostasis 2023 DOI
Bjarne Østerud,
Nadezhda Latysheva,
John Bjarne Hansen,
Omri Snir
:
“A rapid, sensitive, and specific assay to measure tissue factor activity based on chromogenic determination of thrombin generation”: reply
Journal of Thrombosis and Haemostasis 2023 DOI
Steven P. Grover,
Sigrid Kufaas Brækkan,
Nigel Mackman,
John Bjarne Hansen
:
“High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism”: reply
Journal of Thrombosis and Haemostasis 2023 DOI
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Research interests
Kliniske epidemiologi og risikofaktorer for venøs tromboembolisme
Diagnostiske og prediktive biomarkører for venøs tromboembolisme
Patofysiologi ved venøs tromboembolisme
Teaching
2010-2023: Delemneleder i delemne om hematology, immunologi, og infeksjonssykdommer for medisinstudenter ved UiT
2010-2023: Medlem i eksamenskommisjonen for tredje års eksamen for medisinstudenter ved UiT
Member of research group
Member of project
PREVENT
Mission-VTE
Milestone VTE
Genetics and VTE
PEPSI-VTE
Obesity-related VTE
Biomarkers of VTE risk
Diagnostic biomarkers of VTE
Cancer-associated VTE (CAT)
Sex-differences in VTE
Arterial and venous thrombosis
Life-style factors and VTE
VTE recurrence
Extracellular vesicles in thrombogenesis and VTE
Hypoxia-dependent proteins and VTE
Comorbidities and VTE
Risk of bleeding after VTE
Socioeconomic position and VTE
CV
Utdanning
1989: Cand.med (MD), Universitetet i Tromsø
1997: Dr. med (PhD i kardiovaskulær medisin) Universitetet i Tromsø
Tidligere akademiske stillinger
1991-1994: Doktorgradsstudent ved Universitetet i Tromsø
1994-1995: Postdoktor ved Universitetet i Tromsø
1996-2005: Førsteamanuensis i medisin, Universitetet i Tromsø (20-50% stilling)
2005-2008: Professor I i Indremedisin/Hematologi, Universitetet i Tromsø (100% stilling)
2007-2008: Prodekan forskning, Det helsevitenskapelige fakultet, Universitetet i Tromsø
2008-2009: Visiting professor, The Scripps Research Institute, La Jolla, CA, USA
,
Publikasjoner
>300 originale artikler i fagfellevurderte tidsskrift registret i Pubmed, 28 oversiktsartikler, og 12 bokkapitler. Bidratt til >370 abstract presentert ved og pulibsert i forbindelse med internasjonale vitenskapelige konferanser.
Veiledning av PhD-studenter og postdoktorer
Fullførte doktorgrader : Hovedveileder: 35; Biveileder: 5
Pågående doktorgrader: Hovedveileder for 7 og biveileder for 6
Mentor for 13 tidligere postdoktorer og 3 nåværende postdoktorer