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Bilde av Stuge, Tor Brynjar
Department of Medical Biology tor.stuge@uit.no +4777645888 97713935 Tromsø

Tor Brynjar Stuge

  • Trude Victoria, Huiying, Gestur, Stian, Suzanne, Manfred et al.:
    Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody
    ImmunoHorizons 2022 DOI / ARKIV
  • Maria Therese, Gøril, Anne, Bjørn, Jens, Tor Brynjar :
    The prevalence of HPA-1a alloimmunization and the potential risk of FNAIT depend on both the DRB3*01:01 allele and associated DR-DQ haplotypes
    Scandinavian Journal of Immunology 16. avril 2020 DOI / ARKIV
  • Anno, Ivan, Pieter F. Van Der, Tor Brynjar, Jaap Jan, S Marieke van et al.:
    Storage-induced platelet apoptosis is a potential risk factor for alloimmunization upon platelet transfusion
    Frontiers in Immunology 2018 DOI / ARKIV
  • Mariana, Gøril, Heidi, Yan, Nora Hersoug, Inigo Zubiavrre et al.:
    Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: A laboratory study using an in vitro model
    Reproductive Biology and Endocrinology 2017 DOI / ARKIV
  • Heidi, Anne, Maria Therese, Tor Brynjar, Bjørn Ragnar :
    Current perspectives on fetal and neonatal alloimmune thrombocytopenia - Increasing clinical concerns and new treatment opportunities
    International Journal of Women's Health 2017 DOI / ARKIV
  • Jesper, Erle, Maria Therese, Torstein, Tore, Marte K et al.:
    Unraveling the role of maternal anti-HLA class I antibodies in fetal and neonatal thrombocytopenia?Antibody specificity analysis using epitope data
    Journal of Reproductive Immunology 2017 DOI
  • J, Anne, Ganesh, Kari, Tor Brynjar, Bjørn Ragnar et al.:
    Maternal anti-HLA class I antibodies are associated with reduced birthweight in thrombocytopenic neonates
    Journal of Reproductive Immunology 2016 DOI
  • Erin B, Mohadetheh, Tor Brynjar, Sylvie M A, Eva, Melanie :
    A Leukocyte Immune-Type Receptor Subset Is a Marker of Antiviral Cytotoxic Cells in Channel Catfish, Ictalurus punctatus
    Journal of Immunology 2016 DOI
  • Maria Therese, Anne, Ida Løken, Bjørn Ragnar, Tor Brynjar :
    T cell responses to human platelet antigen-1a involve a unique form of indirect allorecognition
    JCI Insight 2016 DOI
  • Laia, Turid, Jack-Ansgar, Ketil Andre, Samer, Tor Brynjar et al.:
    Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation
    Frontiers in Oncology 2015 DOI / ARKIV
  • Mariana, Heidi, Maria, Gøril, Mette Kjær, Cedric et al.:
    Characterization of a human platelet antigen-1a-specific monoclonal antibody derived from a B cell from a woman alloimmunized in pregnancy
    Journal of Immunology 2015 DOI / ARKIV
  • Brile, Tor Brynjar, John P., Georg, Emily, Brian D. et al.:
    Antigen-specific inhibition of high-avidity T cell target lysis by low-avidity T cells via trogocytosis
    Cell reports 2014 DOI
  • Tor Brynjar, Bjørn Ragnar, Maria Therese, Anne, SJ, H :
    The Cellular immunobiology associated with fetal and neonatal alloimmune thrombocytopenia
    Transfusion and Apheresis Science 2011 DOI
  • Gwendolen Y, Holbrook E, Tor Brynjar, Erich J, Jeffrey S, Peter P :
    Cytotoxic T lymphocyte responses against melanocytes and melanoma
    Journal of Translational Medicine 2011 DOI
  • Bjørn Ragnar, Mette Kjær, Jens, Maria Therese, Heidi, Tor Brynjar et al.:
    Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention
    Expert Review of Hematology 2010 DOI
  • Anne, Maria Therese, Mette Kjær, Heidi, Mariana, Ida Løken et al.:
    Blood group antigens and immune responses-detailed knowledge is necessary to prevent immunization and to follow up immunized individuals
    ISBT Science Series 2010
  • Maria Therese, Anne, Mette Kjær, Bjørn Ragnar, Tor Brynjar :
    T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells
    Blood 2009 DOI
  • Mohadetheh, Jason, Mark, Ulla, Evgueni I., Tor Brynjar et al.:
    Characterization of anti-channel catfish MHC class IIβ monoclonal antibodies
    Veterinary Immunology and Immunopathology 2008 DOI
  • Matthew, Micheal T, Jonathan, Jennifer, Jiang, Alexandre et al.:
    Rational design of combination enzyme therapy for celiac sprue.
    Chemistry and Biology 2006 DOI
  • Holbrook E, Chen-Tsen, Tor Brynjar, Susan P, Jeffrey S, Peter P. :
    Rapid assessment of recognition efficiency and functional capacity of antigen-specific T-cell responses.
    Journal of immunotherapy 2005 DOI
  • Daniel S, Yoav, Tor Brynjar, Peter P., Jeffrey S, Patrick O et al.:
    Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray.
    PLoS Medicine 2005 DOI
  • Linling, Tor Brynjar, Eva, Melanie, V. Gregory, John P et al.:
    Identification and characterization of clonal NK-like cells from channel catfish (Ictalurus punctatus).
    Developmental and Comparative Immunology 2004 DOI
  • Tor Brynjar, Susan P, Sahdev, Andrea, Mario, Jeffrey S et al.:
    Diversity and recognition efficiency of T cell responses to cancer.
    PLoS Medicine 2004 DOI
  • Linling, Tor Brynjar, Jason P, Eva, Melanie, V. Gregory et al.:
    Channel catfish NK-like cells are armed with IgM via a putative FcmicroR.
    Developmental and Comparative Immunology 2003 DOI
  • Valerie, Tor Brynjar, Naileshni, Michael R, Jeffrey S, Mario et al.:
    Ex vivo identification, isolation and analysis of tumor-cytolytic T cells.
    Nature Medicine 2003 DOI
  • Jeffrey S, Vernon K, Ronaldo, Ramila, Flora, Valerie et al.:
    Granulocyte-macrophage-colony-stimulating factor added to a multipeptide vaccine for resected Stage II melanoma.
    Cancer 2003 DOI
  • Linling, Tor Brynjar, He, Morad, Katherine S, Sylvie M A et al.:
    Channel catfish cytotoxic cells: a mini-review.
    Developmental and Comparative Immunology 2002 DOI
  • Eva, Sylvie M A, Tor Brynjar, Takayuki, Norman W., L. William et al.:
    The IgH locus of the channel catfish, Ictalurus punctatus, contains multiple constant region gene sequences: different genes encode heavy chains of membrane and secreted IgD.
    Journal of Immunology 2002 DOI
  • Noel A, Jeffrey A, Robert N., Gail, Ronda T, Ann L et al.:
    Extraordinary variation in a diversified family of immune-type receptor genes.
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2001 DOI
  • Helmut, Andrea, Thomas, Beatrice, Tor Brynjar, Lydia et al.:
    A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection.
    International Journal of Cancer 2001 DOI
  • Morad, Tor Brynjar, Melanie, Eva, Norman W., L. William :
    Thioredoxin acts as a B cell growth factor in channel catfish.
    Journal of Immunology 2001 DOI
  • Peter P., F, J, Valerie, Tor Brynjar, Susan G et al.:
    Effects of interleukin-12 on the immune response to a multipeptide vaccine for resected metastatic melanoma.
    Journal of Clinical Oncology 2001 DOI
  • He, Tor Brynjar, Norman W., Eva, John P, Jayne M. et al.:
    Heterogeneity of channel catfish CTL with respect to target recognition and cytotoxic mechanisms employed.
    Journal of Immunology 2001 DOI
  • Katherine S, Sylvie M A, Melanie, Eva, Tor Brynjar, Gregory W et al.:
    Telomerase expression and telomere length in immortal leukocyte lines from channel catfish.
    Developmental and Comparative Immunology 2000 DOI
  • Laia, Turid, Jack-Ansgar, Ketil Andre, Samer, Tor Brynjar et al.:
    Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation
    2015
  • Laia, Turid, Jack-Ansgar, Ketil Andre, Samer, Tor Brynjar et al.:
    Immunoregulatory functions of Cancer-associated Fibroblasts from lung cancers
    2015
  • Ida Løken, Maria Therese, Anne, Bjørn Ragnar, Tor Brynjar :
    Induction and detection of in vivo immune responses to HPA-1a in a novel murine model of fetal/neonatal alloimmune thrombocytopenia (FNAIT)
    2014
  • Jesper, Anne, Ganesh, Kari, Tor Brynjar, Bjørn Ragnar et al.:
    Maternal anti-HLA class 1 antibodies are associated with reduced birth weight in thrombocytopenic neonates
    2014
  • Inigo Zubiavrre, Laia, Tor Brynjar, Turid :
    Immuno-modulatory properties of cancer-associated Fibroblasts and its changes during radiotherapy
    2014
  • Laia, Turid, Tor Brynjar, Inigo Zubiavrre :
    Immunomodulatory properties of Cancer-Associated Fibroblasts
    Anticancer Research 2014
  • Turid, Laia, Tor Brynjar, Inigo Zubiavrre :
    High-dose irradiation does not modify the immunosuppressive effects elicited by cancer-associated fibroblasts
    Anticancer Research 2014
  • Gøril, Tor Brynjar, Bjørn Ragnar, Anne, Maria Therese :
    The DR7-DQ2 Haplotype in a Native Norwegian Population
    Scandinavian Journal of Immunology 2013 DOI
  • Ida Løken, Anne, Maria Therese, M., Bjørn Ragnar, Tor Brynjar :
    ARE CURRENT MURINE MODELS OF FETAL/NEONATAL ALLOIMMUNE THROMBOCYTOPENIA BRINGING US CLOSER TO A BETTER UNDERSTANDING OF PATHOPHYSIOLOGY AND TREATMENT OF THE DISEASE?
    Vox Sanguinis 2013
  • Mariana, Mette Kjær, Anne, Bjørn Ragnar, Tor Brynjar :
    A NOVEL HUMAN MONOCLONAL HPA-1A-SPECIFIC ANTIBODY IS A USEFUL TOOL FOR DIAGNOSTICS IN FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA
    Vox Sanguinis 2013
  • Anne, Heidi, Mette Kjær, Mariana, Maria Therese, Tor Brynjar et al.:
    TOWARDS A PROPHYLACTIC TREATMENT OF HPA-1A-RELATED FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA (FNAIT)
    Vox Sanguinis 2012
  • Anne, Maria Therese, Mette Kjær, Heidi, Mariana, Ida Løken et al.:
    MATERNAL ALLOIMMUNE RESPONSE DURING PREGNANCY: BRAKE OF MATERNAL TOLERANCE TO FETAL HUMAN PLATELET ANTIGEN 1A ANTIGEN MAY BE ASSOCIATED WITH REDUCED PLACENTAL FUNCTION
    Placenta 2011
  • Mariana, Heidi, Anne, Bjørn Ragnar, Tor Brynjar :
    GENERATION OF MONOCLONAL ANTI-HPA-1A ANTIBODIES BY IMMORTALIZATION OF MEMORY B CELLS FROM A WOMAN ALLOIMMUNIZED IN CONNECTION WITH PREGNANCY
    Vox Sanguinis 2010
  • C A, C, Simone S., Ana-Laura Jordan, C, Miriam et al.:
    CD107 surface mobilization of peripheral blood T-cells to predict acute graft-versus-host disease
    Bone Marrow Transplantation 2010
  • Anne, K, Tor Brynjar, H, A, J et al.:
    The knowledge of the pathophysiology of fetal/neonatal alloimmune thrombocytopenia is of importance to prevent immunization and to handle the immunized pregnancies in order to prevent hemorrhage
    Vox Sanguinis 2008
  • Maria Therese, Mette Kjær, Bjørn Ragnar, Anne, Tor Brynjar :
    Isolation and Characterization of CD4+ T Cells Specific for the HPA 1a Epitope Associated with Neonatal Alloimmune Thrombocytopenia
    Blood 2007

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    Publikasjoner utenom Cristin

    Research interests

    Cellular Immunology

    Interplay between T cells and B cells in alloimmune responses

    Fetal and Neonatal Alloimmune Thrombocytopenia


    Member of research group

    Immunology research group   English content

    Member of project

    Prophylaxis to prevent alloimmunization and FNAIT Cellular responses in FNAIT Blood Brain Barrier in FNAIT

    CV

    Born: 1963. Gjøvik, Norway.

    Citizenship: Norwegian.

    Education:

    August 1985 – February 1992:

    Norwegian College of Fishery Science, University of Tromsø, Norway.

     - Master's degree in Marine Biochemistry (February 1992)

    March 1992 – February 1998:

    Dept. of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.

     - PhD degree in Immunology (May 1998)

    Professional Experience:

    February 1998 – February 2000:

    Dept. of Microbiology, University of MississippiMedical Center, Jackson, Mississippi, USA.

     - Postdoctoral Fellow.

    March 2000 – July 2006:

    Division of Hematology, Stanford University School of Medicine, Palo Alto, California, USA.

     - Postdoctoral Fellow/Research Associate.

    September 2006 – present:                                                                                                  

    Immunology Research Group, Department of Medical Biology, University of Tromsø – The Arctic University of Norway, Tromsø, Norway.

     - Professor since September 2011.

     - Leader, Immunology Research Group since August 2013.

     

    Résumé:

    I am a native of Norway and currently a professor at the University of Tromsø - The Arctic University of Norway. My current research focus is immune responses associated with Fetal and Neonatal Alloimmune Thrombocytopenia - a condition caused by maternal antibodies reactive with fetal platelets - and especially the nature of maternal T cell responses that leads to this condition. Earlier in my career, I worked with T cell responses in cancer patients and in fish

     

    Mentorship:

    I have served as principal mentor for 4 doctoral students: Maria Therese Ahlen, PhD, graduated 2011; Mariana Eksteen, PhD, graduated 2015; Gøril Heide, MD, will defend her PhD thesis in 2018; Ida Løken Killie will defend her PhD thesis 2018. In addition, I have served as co-mentor for 3 PhD students. I have also mentored 4 master's degree students and two "Forskerlinje" students ("Forskerlinje" is a medical school research graduate program). I have also mentored a number of medical students and hosted six visiting international students involved in research assignments in our laboratory. I was also a member of the PhD committee for Carina Bauerlein, a student in the research group of Dr. Andreas Beilhack at the University of Wurzburg, Germany. Graduated summer 2013.                            

     

    Teaching:

    I have been teaching continuously since fall 2006. I lecture for students in medical, dental, and graduate schools. I also teach by leading discussion groups and in laboratory classes. Mainly, I teach immunology, although I also teach a class in the philosophy of science. On average, I teach about 90 hours per year. In addition, I am responsible for arranging and coordinating several different courses and I am a permanent member of several different exam commissions. I also serve as the immunology teaching coordinator for the Institute of Medical Biology.

    Patents/Patent applications:

    1.         Methods and compositions for producing target cell reactive lymphocytes in a subject.      Inventors: Peter P. Lee and Tor B. Stuge (2006). Pub. nr: WO2006020319 A3

    2.         Treatment of neonatal alloimmune thrombocytopenia. Pub. Nr: WO 2014131856 A1

                Inventors: Tor B Stuge, Bjørn R Skogen, Anne Husebekk, Maria Therese Ahlen (2014)

    3.         Antibodies against HPA-1a. Pub. nr: WO 2015150417 A1

                 Inventors: Tor Brynjar Stuge, Mariana Eksteen, Heidi Tiller, Terje Michaelsen, Øistein Ihle, Anne   Husebekk, Bjørn Ragnar Skogen (2015)