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Bilde av Sørensen, Karen Kristine
Bilde av Sørensen, Karen Kristine
Department of Medical Biology karen.sorensen@uit.no +4777644685 Tromsø You can find me here

Karen Kristine Sørensen

Job description

Forskning og undervisning.

 

 

 

  • Javier Sanchez, Jaione, Peter Anthony, Bård Helge, Kim Erlend, Antonia et al.:
    Liver sinusoidal cells eliminate blood-borne phage K1F
    mSphere 2024 DOI / ARKIV
  • Karolina Joanna, Karen Kristine, Patricia F., Peter Anthony :
    Sinusoidal cells and liver immunology
    2024 DOI / ARKIV
  • Sabin, Ingelin Kyrrestad, Jaione, Ruomei, Karolina Joanna, Gianina Aurica et al.:
    Mouse liver sinusoidal endothelial cell responses to the glucocorticoid receptor agonist dexamethasone
    Frontiers in Pharmacology 2024 DOI / ARKIV
  • Ingelin Kyrrestad, Anett Kristin, Javier Sanchez, Jaione Santamaria, Ruomei, Karen Kristine :
    Infection of liver sinusoidal endothelial cells with Muromegalovirus muridbeta1 involves binding to neuropilin-1 and is dynamin-dependent
    Frontiers in Cellular and Infection Microbiology 2023 DOI / ARKIV
  • Milton Boaheng, Gianina Aurica, Jaione Santamaria, Javier Sanchez, Ruomei, Bård et al.:
    Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the Glmp gt/gt mouse model of slowly progressing liver fibrosis
    PLOS ONE 2023 DOI / ARKIV
  • Ruomei, Sabin, Inigo Zubiavrre, Jack-Ansgar, Ilona Halva, Bård et al.:
    Changes in the proteome and secretome of rat liver sinusoidal endothelial cells during early primary culture and effects of dexamethasone
    PLOS ONE 2022 DOI / ARKIV
  • Anett Kristin, Jaione, kjetil helge, Bo Gøran, Kim Erlend, Peter Anthony et al.:
    Autofluorescence in freshly isolated adult human liver sinusoidal cells
    European journal of histochemistry 2021 DOI / ARKIV
  • Sabin, Anett Kristin, Peter Anthony, Bård, Karen Kristine :
    The scavenger function of liver sinusoidal endothelial cells in health and disease
    Frontiers in Physiology 11. octobre 2021 DOI / ARKIV
  • Sabin, Ruomei, Jaione, Peter Anthony, Steinar Daae, Bård et al.:
    Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages
    BMC Molecular and Cell Biology 2020 DOI / ARKIV
  • Javier Sanchez, Karen Kristine, Anett Kristin, Torill, Morten :
    Ocular Histopathological Findings in Semi-Domesticated Eurasian Tundra Reindeer (Rangifer tarandus tarandus) with Infectious Keratoconjunctivitis after Experimental Inoculation with Cervid Herpesvirus 2
    Viruses 2020 DOI / ARKIV / FULLTEKST
  • Karen Kristine, Bård :
    The Liver Sinusoidal Endothelial Cell: Basic Biology and Pathobiology
    2020
  • Cristina Ionica, Deanna, Tanji, Gianina, Karen Kristine, Peter Anthony et al.:
    Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses.
    Scientific Reports 2020 DOI / ARKIV
  • Anett Kristin, Ingebjørg Helena, Karen Kristine, Marit, Rolf, María Pilar Jiménez de et al.:
    Concomitant Temperature Stress and Immune Activation may Increase Mortality Despite Efficient Clearance of an Intracellular Bacterial Infection in Atlantic Cod
    Frontiers in Microbiology 2018 DOI / ARKIV
  • Bo Wold, Jaione, Ulf Thore, Einar, Jack-Ansgar, Vibeke Barman et al.:
    Dose- and time-dependent effects of triethylene glycol dimethacrylate on the proteome of human THP-1 monocytes
    European Journal of Oral Sciences 2018 DOI / ARKIV
  • Morten, Javier Sanchez, Nina, Ingebjørg Helena, Terje D., Karen Kristine et al.:
    Cervid herpesvirus 2 and not Moraxella bovoculi caused keratoconjunctivitis in experimentally inoculated semi-domesticated Eurasian tundra reindeer
    Acta Veterinaria Scandinavica (AVS) 2017 DOI / ARKIV
  • Bo Wold, Ulf Thore, Jaione, Karen Kristine, Vibeke Barman :
    Methods and terminology used in cell-culture studies of low-dose effects of matrix constituents of polymer resin-based dental materials
    European Journal of Oral Sciences 2016 DOI
  • Karen Kristine, Jaione, Robert S., Bård :
    Liver sinusoidal endothelial cells
    Comprehensive Physiology 2015 DOI
  • Ingelin Kyrrestad, Anett Kristin, Javier Sanchez, Jaione Santamaria, Ruomei, Karen Kristine :
    The dynamin-inhibitor dynasore blocks cytomegalovirus infection in primary mouse liver sinusoidal endothelial cells
    2023
  • Javier Sanchez, Jaione Santamaria, Peter Anthony Gerard, Christopher Florian, Bård, Antonia et al.:
    Rapid blood clearance of phage K1F-GFP is mediated by the liver and executed by Kupffer cells and liver sinusoidal endothelial cells in collaboration
    2023
  • Anett Kristin, Javier Sanchez, Jaione Santamaria, Kim Erlend, Ingelin Kyrrestad, Eirik Abrahamsen et al.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream.
    Journal of Hepatology 2023 DOI
  • Emma L., Ellie, Pantelitsa, Karolina, Karen Kristine, Patricia F. :
    Decellularization of the Human Liver to Generate Native Extracellular Matrix for Use in Automated Functional Assays with Stellate Cells
    Methods in molecular biology 2023 DOI
  • Ingelin Kyrrestad, Anett Kristin, Javier Sanchez, Jaione Santamaria, Ruomei, Karen Kristine :
    Dynamin-inhibitors dynasore and MitMAB block muromegalovirus muridbeta1 infection in liver sinusoidal endothelial cells.
    2023
  • Javier Sanchez, Anett Kristin, Jaione, Cristina Ionica, Bård, Peter Anthony et al.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Anett Kristin, Javier Sanchez, Eirik Abrahamsen, Anne Lotte Vada, Jaione, Kim Erlend et al.:
    Liver sinusoidal scavenger cells eliminate betaherpesvirus from the blood stream
    2022
  • Anett Kristin, Javier Sanchez, Jaione, Kim Erlend, Bo Gøran, Peter Anthony et al.:
    Role of liver sinusoidal endothelial cells in elimination of virus
    2022
  • Javier Sanchez, Anett Kristin, Jaione, Cristina Ionica, Bård, Peter Anthony et al.:
    The role of scavenger endothelial cells in bacteriophage pharmacokinetics
    2022
  • Ingelin, Javier Sanchez, Anett Kristin, Ruomei, Jaione, Kenneth Bowitz et al.:
    Effect of dynamin inhibitor dynasore on primary mouse liver sinusoidal endothelial cells (LSEC)
    2022
  • Javier Sanchez, Morten, Ingebjørg Helena, Anett Kristin, Karen Kristine :
    Infectious keratoconjunctivitis in reindeer - The role of the reindeer alphaherpesvirus
    UiT Norges arktiske universitet 2019
  • Javier Sanchez, Anett Kristin, kjetil helge, Christopher Florian, Jaione, Hans H. et al.:
    SECVIR - The role of scavenger endothelial cells in elimination of virus
    2019
  • Ingelin, Ruomei, Sabin, Jaione, Bård, Karen Kristine :
    A protocol for in vitro toxicity studies in liver sinusoidal endothelial cells
    2019
  • Karen Kristine, Milton Boaheng, Gianina, Ruomei, Bård, Winnie :
    Scavenger function of liver sinusoidal endothelial cells in a transgenic mouse model of liver fibrosis is reduced
    2019
  • Sabin, Ruomei, Ingelin, Jack-Ansgar, Ilona, Bård et al.:
    Effect of glucocorticoids on liver sinusoidal endothelial cells in vitro
    2019
  • Anett Kristin, Jaione, kjetil helge, Bo G., Bård, Karen Kristine :
    Autofluorescence in freshly isolated adult human liver sinusoidal cells
    2019
  • Deanna, Cristina Ionica, Tanji, Gianina, Peter Anthony, Karen Kristine et al.:
    Uptake and Degradation of Bacteriophages by Liver Sinusoidal Endothelial Cells
    2018 ARKIV
  • Javier Sanchez, Karen Kristine, Ingebjørg Helena, Torill, Morten :
    Histopathological study of eye tissues from semi-domesticated reindeer with infectious keratoconjunctivitis caused by cervid herpesvirus 2 in an experimental setting
    2018
  • Javier Sanchez, Morten, John A., Torill, Ingebjørg Helena, Karen Kristine :
    The pathogenic role of Moraxella bovoculi in infectious keratoconjunctivitis in semi-domesticated reindeer
    2017
  • Hong, Cristina Ionica, Ruomei, Ana, Karen Kristine, Deanna et al.:
    Disruption of rat liver sinusoidal endothelial cell morphology by oxidised low density lipoproteins
    2017
  • Hong, Cristina Ionica, Ruomei, Ana, Karen Kristine, Deanna et al.:
    Using super-resolution microscopy to image disruption of liver sinusoidal endothelial cell morphology by oxidized low-density lipoproteins
    2017
  • Sabin, Ruomei, Jaione, Peter Anthony, Steinar Daae, Bård et al.:
    The liver sinusoidal endothelial cell – an endothelial cell with a macrophage-like identity
    2017
  • Ruomei, Jaione, Sabin, Jack-Ansgar, Ilona, Bård et al.:
    Phenotypic changes in rat liver sinusoidal endothelial cells during early stages of in vitro culture
    2017
  • Deanna, Cristina Ionica, Yasunori, Karen Kristine, Peter Anthony, Bård et al.:
    Multimodal Microscopy to Study the Fate of Bacteriophages in Liver Sinusoidal Endothelial Cells
    2017
  • Bo Wold, Ulf Thore, Jaione, Karen Kristine, Vibeke Barman :
    Low-grade toxicity of matrix constituents of polymer resin based dental materials - A review of terminology and methods
    2016
  • Sabin, Ruomei, Jaione, Peter Anthony, Steinar Daae, Bård et al.:
    Next generation deep sequencing of rat liver sinusoidal endothelial cell and Kupffer cell transcriptomes suggests functional complementarity
    2016
  • Jaione, Ruomei, Sabin, Jack-Ansgar, Bård, Inigo Zubiavrre et al.:
    Secretome of the liver sinusoidal endothelial cell
    2016
  • Peter Anthony, Ana, Melonie J., Brenda, Chad K., Karen Kristine et al.:
    Identification of adult hemogenic sinusoidal endothelial cells in adult bone marrow.
    2016
  • Hong, Cristina Ionica, Ruomei, Ana, Karen Kristine, Deanna et al.:
    Disruption of liver sinusoidal endothelial cell morphology by oxidized low–density lipoproteins
    2016
  • Peter Anthony, Thomas Rolf, Karen Kristine, Cristina Ionica, Viola, Balpreet Singh :
    Optical microscopy to reveal structural and functional properties of liver cells.
    2015
  • Javier Sanchez, Morten, Ingebjørg Helena, Torill, Terje D., Karen Kristine :
    Severe transmissible eye infection in reindeer: bacterium or virus?
    2015
  • Morten, Javier Sanchez, Nina, P, OC, Torill et al.:
    Reindeer alphaherpesvirus (CvHV2) and not Moraxella bovoculi caused infectious keratoconjunctivitis experimentally in semi-domesticated reindeer (Rangifer tarandus tarandus)
    2015
  • Morten, Javier Sanchez, Nina, Karen Kristine, Ingebjørg Helena, Terje D. et al.:
    The cause of infectious keratoconjunctivitis in semi-domesticated reindeer - an experimental approach
    2015

    • The 50 latest publications is shown on this page. See all publications in Cristin here →

    Research interests

    • Liver sinusoidal endothelial cell (LSEC) biology
    • Scavenger function of LSEC in health and disease
    • Role of liver sinusoidal cells in the elimination of virus
    • Comparative and developmental aspects of scavenger endothelial cells

    Teaching

    Underviser i cellebiologi, fysiologi, histologi og elektronmikroskopi i emner tilknyttet utdanningene i medisin, odontologi, bioingeniør, og bachelor/master/PhD i biomedisin. 

     


    Member of research group

    Vascular Biology   English content Vaskulær biologi   Norsk innhold Marie Skłodowska-Curie Actions   English content

    Member of project

    EIC DeLIVERY SECVIR

    CV

    Utdanning
    1989: Veterinærmedisinsk embetseksamen, Norges Veterinærhøgskole, Oslo
    1999: PhD i biologi, Universitetet i Tromsø

    Yrkespraksis
    1989-90: Avdelingsveterinær, Næringsmiddeltilsynet i Sortland og Øksnes
    1991-93: Klinisk stordyrpraksis, Leirfjord og Suldal
    1994-98: NFR-stipendiat, Avdeling for arktisk veterinærmedisin, NVH, Tromsø.
    1998-03: Forsker (patologi, mikrobiologi, laboratoriediagnostikk), Veterinærinstituttet Tromsø
    2003-06: Postdoktor (NFR), IMB, Avdeling for cellebiologi og histologi, UiT
    2005, 2007: Førsteamanuensis, vikariat, IMB, Avdeling for cellebiologi og histologi, UiT
    2007-10: Postdoktor/forsker, finansiert av Tromsø forskningsstiftelse og IMB, UiT
    2011-2013: Førsteamanuensis, Vaskulærbiologisk forskningsgruppe, IMB,UiT

    2013- : Professor, Vaskulærbiologisk forskningsgruppe, IMB, UiT. Forskningsgruppeleder fra 2020.

     

    MH øst L8.240F


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