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Bilde av Fenton, Kristin Andreassen
Bilde av Fenton, Kristin Andreassen
Department of Medical Biology kristin.fenton@uit.no +4777646834 Tromsø You can find me here

Kristin Andreassen Fenton

Job description

Jeg er utdannet molekylærbiolog med hovedfag i biokjemi og har en PhD i immunologi. Mitt forskningsområde dekker molekylær biologi innen immunologi og autoimmunitet, Jeg forsker på sykdomsmekanismene som fører til utvikling av den autoimmune sykdommen systemisk lupus erythematosus (SLE) og spesielt utviklingen av lupus nefritt (LN). Vårt mål er å kunne stille diagnosen på et tidligere stadium og utvikle nye pasient spesifikke behandlings strategier.

 

Jeg underviser immunologi og autoimmunitet til BSc og MSc i biomedisin og medisin studenter. Jeg er også ansvarlig for bachelor oppgaven i biomedisin (MBI-2010).

 

Jeg er i tillegg nestleder utdanning ved institutt for medisinsk biologi der jeg har ansvar for alle undervisere og all undervisning som gis av IMB.

  • Huimin, Li, Kristin Andreassen, Xiaobo :
    Exploring and evaluating microbiome resilience in the gut
    FEMS Microbiology Ecology 2025 DOI
  • Susannah von, Kristin Andreassen, Hege Lynum :
    Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus
    International Journal of Molecular Sciences 2024 DOI / ARKIV
  • Aud-Malin Karlsson, Saba, Charlotte G, Premasany, Valentina, Francesca et al.:
    Podoplanin expressing macrophages and their involvement in tertiary lymphoid structures in mouse models of Sjögren’s disease
    Frontiers in Immunology 2024 DOI / ARKIV
  • Kristin Andreassen, Hege Lynum :
    Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus
    Frontiers in Medicine 2023 DOI / ARKIV
  • Luis, Vishesh Kumar, Mona, Jean-Claude, David Andre, Firehun Tsige et al.:
    Chip-based multimodal super-resolution microscopy for histological investigations of cryopreserved tissue sections
    Light: Science & Applications (LSA) 2022 DOI / ARKIV
  • Luis, Vishesh Kumar, Jean-Claude, David Andre, Anish, Sebastian Andres Acuña et al.:
    Photonic-chip: a multimodal imaging tool for histopathology.
    Journal of the Optical Society of America. B, Optical physics 2021 DOI / ARKIV
  • Seyed Esmaeil, Ana, Samuel, Armas Maria Montserrat, Premasany, Sara et al.:
    Positron emission tomography and single photon emission computed tomography imaging of tertiary lymphoid structures during the development of lupus nephritis
    International Journal of Immunopathology and Pharmacology 2021 DOI / ARKIV
  • Simin, Mehrdad, Reza, George, Kristin Andreassen :
    Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis
    Autoimmunity Reviews 2021 DOI / ARKIV
  • Seyed Esmaeil, Premasany, Aud-Malin Karlsson, Mikael Ryan, Kjersti Daae, anita et al.:
    Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature
    American Journal of Pathology 2020 DOI / ARKIV
  • Samuel, Kristoffer Knutsen, Gustav, Seyed Esmaeil, Montserrat, Ana et al.:
    Machine learning derived input-function in a dynamic 18F-FDG PET study of mice
    Biomedical Engineering & Physics Express 2020 DOI / ARKIV
  • Seyed Esmaeil, Aud-Malin Karlsson, Premasany, Gunnstein, Gro Østli, Stine et al.:
    Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis
    Scientific Reports 2018 DOI / ARKIV
  • Stine, Erik, Ilona, Christopher Graham, Bryan, Maria et al.:
    ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes
    Scientific Reports 2018 DOI / ARKIV
  • Kristin Andreassen :
    The effect of cell death in the initiation of lupus nephritis
    Clinical and Experimental Immunology 2015 DOI / ARKIV
  • Stine Linn, Silje, Kristin Andreassen, Christopher Graham, Elin Synnøve :
    Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients
    BMC Cancer 2015 DOI / ARKIV
  • Premasany, Annica, Christopher Graham, Kristin Andreassen :
    Nucleosomes contribute to increase mesangial cell chemokine expression during the development of lupus nephritis
    Cytokine 2013 DOI
  • Annica, Premasany, Ole Petter, Kristin Andreassen :
    LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice
    Clinical & Developmental Immunology 2013 DOI / ARKIV
  • Idun, Lise, Kristin Andreassen, Beate, Kaare Magne, Susan et al.:
    Uptake and Organ Distribution of Feed Introduced Plasmid DNA in Growing or Pregnant Rats
    Food and Nutrition Sciences 2011 DOI
  • Janne erikke, Ole Petter, Johan van der, Kristin Andreassen :
    Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens
    Autoimmunity 2011 DOI
  • Annica, Silje, Kristin Andreassen, Christopher Graham, Bjarne, Elin et al.:
    Heparin Exerts a Dual Effect on Murine Lupus Nephritis by Enhancing Enzymatic Chromatin Degradation and Preventing Chromatin Binding in Glomerular Membranes
    Arthritis and Rheumatism 2011 DOI
  • Mariann Hellvik, Ole Petter, Rasmus S., Søren, Kristin Andreassen :
    Circulating levels of chromatin fragments are inversely correlated with anti-dsDNA antibody levels in human and murine systemic lupus erythematosus
    Immunology Letters 2011 DOI
  • Kristin Andreassen, berit, Tony Norman, Ole Petter :
    Pure anti-dsDNA mAbs need chromatin structures to promote glomerular mesangial deposits in BALB/c mice
    Autoimmunity 2010 DOI
  • Annica, Silje, Kristin Andreassen, Elin, Ole Petter :
    Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities
    Experimental Dermatology 2010 DOI
  • Kristin Andreassen, Silje, Annica, Natalya, Christopher Graham, Elin et al.:
    Anti-dsDNA Antibodies Promote Initiation, and Acquired Loss of Renal Dnase1 Promotes Progression of Lupus Nephritis in Autoimmune (NZBxNZW)F1 mice
    PLOS ONE 2009 DOI / ARKIV
  • Kristin Andreassen, berit, Tony Norman, Ole Petter :
    Pure anti-dsDNA mAbs need chromatin structures to promote glomerular mesangial deposits in BALB/c mice
    Autoimmunity 2009 DOI
  • Silje, Annica, Kristin Andreassen, S, E, AL et al.:
    Circulating chromatin-anti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis
    Lupus 2009 DOI
  • Kristin Andreassen, Janne erikke, Søren, randi, Ole Petter :
    Renal expression of polyomavirus large T antigen is associated with nephritis in human systemic lupus erythematosus
    Molecular Immunology 2008 DOI
  • signy, Elin, randi, Kristin Andreassen, manar, Leif et al.:
    Glomerular expression of large polyomavirus T antigen in binary tet-off regulated transgenic mice induces apoptosis, release of chromatin and initiates a lupus-like nephritis
    Molecular Immunology 2008 DOI
  • Elin, Kristin Andreassen, Ole Petter :
    Lupus nephritis - The central role of nucleosomes revealed
    American Journal of Pathology 2008 DOI
  • Casandra C. van, Kristin Andreassen, Ole Petter, Johan van der, Jo H. :
    Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus
    Arthritis and Rheumatism 2008 DOI
  • manar, Kristin Andreassen, Elin, randi, G, P et al.:
    Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis
    Kidney International 2007 DOI
  • Janne erikke, Ole Petter, Kristin Andreassen :
    Nucleosomes possess a high affinity for glomerular laminin and collagen IV and bind nephritogenic antibodies in murine lupus-like nephritis
    Annals of the Rheumatic Diseases 2007 DOI
  • Kristin Andreassen, Ole Petter :
    A central role of nucleosomes in lupus nephritis
    Annals of the New York Academy of Sciences 2007 DOI
  • Marit Renee, Kristin Andreassen, Julia Friederike, Kaare Magne, Terje I :
    The 35S CaMV plant virus promoter is active in human enterocyte-like cells
    European Food Research and Technology 2006 DOI
  • Aud-Malin Karlsson, Premasany, Thea Ekrem, anita, Stine, Susannah von et al.:
    Early imiquimod-induced onset of disease in lupus-prone NZBW-F1 mice
    2025
  • Luis, Vishesh Kumar, Mona, Kristin Andreassen, Ganesh, Jose M. et al.:
    Chip-based multimodal microscopy for histological investigations of cryopreserved tissue sections
    2022
  • Samuel, Luigi Tommaso, Kristoffer, Nils Thomas Doherty, Seyed Esmaeil, Ana et al.:
    Deep learning derived input function in dynamic 18F-FDG PET imaging of mice
    2022
  • Thea, Aud-Malin Karlsson, Premasany, Anita, Charlotte, Stine et al.:
    IL-18 deficiency does not affect development of renal tertiary lymphoid structures in imiquimod induced SLE
    Lupus Science and Medicine 2022 DOI
  • Vishesh Kumar, Luis Enrique Villegas, Mona, Jean-Claude, David Andre, Firehun Tsige et al.:
    Photonic-chip for multimodal super-resolution imaging in histopathology applications
    2021
  • Vishesh Kumar, Luis Enrique Villegas, Jean-Claude, David Andre, Anish, Sebastian et al.:
    Multimodal super-resolution imaging for histopathology applications
    2021
  • Kristin Andreassen, Hege Lynum :
    Characterising tertiary lymphoid structures in lupus-prone mice
    Research Features Magazine 05. mai 2021 DOI
  • Kristin Andreassen, Stine, Elin Synnøve :
    ICAM1 er uttrykt i trippel negative brystkreftceller og vev
    BestPractice nordic 2018
  • Kristin Andreassen, Janne erikke, R, manar, Ole Petter :
    Electron dense deposits in the GBM of (NZBxNZW)F1 mice constitute chromatin that represents target for in vivo bound autoantibodies
    2006
  • Julia Friederike, Kristin Andreassen, olga, Beate, AI, Lise et al.:
    Absence of Proof is not a Proof of Absence. Risks of Genetically Modified Organisms
    2002

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    Research interests

    Mitt hovedmål er å utvikle nye diagnostiske markører og ikke invasive avbildningsmetoder som kan føre til tidligere påvisning av lupus nefritt hos SLE pasienter.

    SLE er blant annet karakterisert av at autoantistoffer binder seg i nyrene og disse nedslagene fortykker membranene som igjen fører til nyresvikt. Autoantistoffer og kromatin aktiverer nyreceller og er viktige for initieringen av nyrebetennelse (lupus nefritt). Vi kartlegger derfor rollen til spesialiserte celler som endotel- og mesangial celler i nyrene under utviklingen av lupus nefritt. I tillegg er det gjort lite forskning på hvilken rolle andre celler i nyrene som tubuliceller, makrofager og dendrittiske celler, har i interstitiell inflammasjon. Vi fokuserer på hvilken effekt inflammasjon i disse cellene har på utviklingen av nyreaffeksjon i SLE. I tillegg har vi oppdaget nye strukturer som dannes i nyrer som er inflammerte, såkalte tertiære lymfoide strukturer (TLS). Disse har samme oppbygning som lymfeknuter, men mangler kapsel. Ved hjelp av genteknologiske og immunologiske analyser av humant nyrevev karakteriserer vi hvilken rolle de ovennevnte cellene og strukturene har i utviklingen av human lupus nefritt. Vårt må er å etablere og utføre klinisk PET/MRI undersøkelse på SLE pasienter med og uten nyreaffeksjon basert på prekliniske PET/MRI og PET/CT studier på lupus mus.

    Researcher profile in Cristin
    ResearchGate
    ORCID: https://orcid.org/0000-0002-8356-2628

    Member of research group

    RNA and molecular pathology research group (RAMP)   Norsk innhold

    Member of project

    Lupus Nephritis-disease mechanisms, detection and therapy Human Lupus Nephritis
    MH øst L9.129


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