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Clinical bioinformatics ruth.h.paulssen@uit.no +4777645480 +4740479347 +47 40479347 Tromsø You can find me here

Ruth H Paulssen

Job description

Forskningsgruppeleder  Klinisk Bioinformatikk

Leder for Genomics Support Centre Tromsø (GSCT)

  • Leon, Rasmus, Christopher Graham, Ruth Erika Hildegard Hracky, Henning :
    Impact of fecal microbiota transplantation in dogs
    Frontiers in Veterinary Science 2025 DOI
  • Line Strand, Rafi, Hagar, Christopher Graham, Ruth H :
    Actively expressed microbiota in tissue biopsies of treatment-naive ulcerative colitis patients
    Gut Microbes Reports 2025 DOI
  • Christopher Graham, Mithlesh Kumar, Ruth Erika Hildegard Hracky :
    Challenges in Defining a Reference Set of Differentially Expressed lncRNAs in Ulcerative Colitis by Meta-Analysis
    Current Issues in Molecular Biology 2024 DOI / ARKIV
  • Wei, Christopher Graham, Kay-Martin, Hagar, Jon, Ruth Erika Hildegard Hracky :
    DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies
    Scientific Reports 2024 DOI / ARKIV
  • Alicia, Vincent, Aurora Bernal, Carlos, Itziar, Alberto et al.:
    Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
    Nature Communications 2023 DOI / ARKIV
  • Sanda, Karina Standahl, Endre, Jan Ole, Eiliv, Ruth H :
    Associations of breast cancer related exposures and gene expression profiles in normal breast tissue - The Norwegian Women and Cancer normal breast tissue study
    Cancer Reports 2023 DOI / ARKIV
  • Wei, Kay-Martin, Christopher Graham, Jon, Ruth H :
    Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis
    Functional & Integrative Genomics 2023 DOI / ARKIV
  • Christopher Graham, Mithlesh Kumar, Wei, Ruth H :
    Methylation-Regulated Long Non-Coding RNA Expression in Ulcerative Colitis
    International Journal of Molecular Sciences 2023 DOI / ARKIV
  • Amrinder, Christopher Graham, Endre, Ruth H :
    Identifying predictive signalling networks for Vedolizumab response in ulcerative colitis
    International Journal of Colorectal Disease 11. mai 2022 DOI / ARKIV
  • Mithlesh Kumar, Christopher Graham, Ruth H :
    Novel long non-coding RNAs of relevance for ulcerative colitis pathogenesis
    Non-coding RNA Research 2022 DOI / ARKIV
  • Amrinder, Endre, Christopher Graham, Ruth H :
    Identifying anti-TNF response biomarkers in ulcerative colitis using a diffusion-based signalling model
    Bioinformatics Advances 2021 DOI / ARKIV
  • Eva-Stina Isabella, Christopher Graham, Stanislas, Ruth H, Marie-Paule, Pierre et al.:
    Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids
    Frontiers in Immunology 28. octobre 2021 DOI / ARKIV
  • Hagar, Christopher Graham, Endre, Jon, Ruth H :
    DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis
    PLOS ONE 2021 DOI / ARKIV
  • Christopher Graham, Hagar, Jon, Sveinung, Ruth H :
    Transcriptional signatures that define ulcerative colitis in remission
    Inflammatory Bowel Diseases 2020 DOI / ARKIV
  • Mona Dixon, Rasmus, Christopher Graham, Endre, Sveinung Wergeland, Jon et al.:
    Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis
    Clinical and Translational Gastroenterology 2019 DOI / ARKIV
  • Hagar, Christopher Graham, Inga Viktoria, Endre, Jon, Ruth H :
    Genome-Wide DNA Methylation in Treatment-Naïve Ulcerative Colitis
    Journal - Crohn's and Colitis Foundation of Canada 2018 DOI / ARKIV
  • Hagar Mohamed, Christopher Graham, Inga Viktoria, Endre, Jon, Ruth H :
    Transcriptomic Landscape of Treatment-Naïve Ulcerative Colitis
    Journal of Crohn's and Colitis 2018 DOI / ARKIV
  • Armin, Endre, Christopher Graham, Rasmus, Yvonne, Ruth H et al.:
    The Proteome of Ulcerative Colitis in Colon Biopsies from Adults - Optimized Sample Preparation and Comparison with Healthy Controls
    PROTEOMICS - Clinical Applications 2017 DOI
  • Yvonne, Christopher Graham, Rolf, Ruth H :
    Changes in the human transcriptome upon vitamin D supplementation
    Journal of Steroid Biochemistry and Molecular Biology 2017 DOI / ARKIV
  • Åse, Rasmus, Ole-Martin, Ingvild, Ruth H, Arthur et al.:
    The impact of partial hepatectomy on oxidative state in the liver remnant - An in vivo swine model
    Redox Biology 2016 DOI / ARKIV
  • Kenneth, Sveinung Wergeland, Marit Nina, Ruth H :
    Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: Co-expression of Drosha and miR-126 predicts poor survival
    BMC Clinical Pathology 11. décembre 2014 DOI / ARKIV / FULLTEKST
  • Inigo Zubiavrre, Christopher Graham, Hagar Mohamed, ingvild, Turid, Ruth H :
    Tumorigenic responses of Cancer-Associated Fibroblasts after ablative radiotherapy: A transcriptome-profiling study
    Journal of Cancer Therapy 2013 DOI
  • Karina Standahl, Christopher Graham, Livar, Marit, Ruth H, Eiliv :
    Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort
    PLOS ONE 2013 DOI / ARKIV
  • Turid, ingvild, Vivian, Jan-Olof, Bjørn Torvald Greve, Kristian et al.:
    Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced
    Radiation Oncology 2012 DOI / ARKIV
  • Vasilis, Christopher Graham, Ruth H, Åse, Ganesh :
    Differences in Gene Expression between First and Third Trimester Human Placenta: A Microarray Study
    PLOS ONE 2012 DOI / ARKIV
  • Kristin, Christopher Graham, Jørn, Guanglin, Endre, Ruth H :
    New specific molecular targets for radio-chemotherapy of rectal cancer
    Molecular Oncology 2010 DOI
  • vanessa, Karina Standahl, G, Ruth H, Anne-Lise, Eiliv :
    Deciphering Normal Blood Gene Expression Variation-The NOWAC Postgenome Study
    PLoS Genetics 2010 DOI / ARKIV
  • hege lynum, erik, steinar, Hilde, Lotte, Sunniva Katharina et al.:
    Global responses of Aliivibrio salmonicida to hydrogen peroxide as revealed by microarray analysis
    Marine Genomics 2010 DOI
  • Vasilis, Ruth H, Jørn, Åse, Ganesh :
    Placental Gene Expression Profile in Intrauterine Growth Restriction Due to Placental Insufficiency
    Reproductive Sciences 2009 DOI
  • Vasilis, Ruth H, Halvor, Jørn, Tor-Arne, Åse et al.:
    Differential Placental Gene Expression in Severe Preeclampsia
    Placenta 2009 DOI
  • Vincent, Joanna, Aurora Bernal, Marc Ferre, Manuel José, Nuria et al.:
    Succinate receptor 1 signaling regulates hematopoiesis via S100/a8 and S100/a9 in health and malignancy
    2024
  • Vincent, Joanna, Emeline, Aurora Bernal, Marc Ferré, Manuel José et al.:
    Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression
    2024
  • Alicia Elena Villatoro, Vincent, Aurora Bernal, Carlos, Itziar, Alberto et al.:
    Author Correction: Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation (Nature Communications, (2023), 14, 1, (12), 10.1038/s41467-022-35700-9)
    Nature Communications 2023 DOI
  • Wei, Mithlesh Kumar, Christopher Graham, Endre, Ruth H :
    Analysis of methylation data with imputation with blocks (MethylBlocks)
    2022 ARKIV
  • Mithlesh Kumar, Christopher Graham, Ruth H :
    Novel long-coding RNAs of relevance for ulcerative colitis pathogenesis
    2022 ARKIV
  • Karina Standahl, Sanda, Endre, Frantzen, Eiliv, Ruth H :
    Associations of breast cancer related exposures and gene expression profiles in normal breast tissue
    2021
  • Christopher Graham, Hagar, Jon, Ruth H :
    Transcriptional profiling of ulcerative colitis in remission
    2019
  • Christopher Graham, Hagar, Jon, Ruth H :
    Transcriptional profiling of ulcerative colitis in remission
    Journal of Crohn's and Colitis 25. janvier 2019 DOI / ARKIV
  • Ruth H, Hagar Mohamed, Christopher Graham, Inga Viktoria, Endre, Jon :
    Novel regulatory DNA methylation features of relevance for ulcerative colitis
    American Journal of Gastroenterology 2018 DOI
  • Ruth H, Hagar Mohamed, Christopher Graham, Inga Viktoria, Endre, Jon :
    Novel regulatory DNA methylation features of relevance for ulcerative colitis
    2017
  • Mona Dixon, Rasmus, Jon, Ruth H :
    Mucosal healing in active ulcerative colitis treated with infliximab to disease remission
    Inflammatory Bowel Diseases 2016
  • Ruth H, Rasmus, Jon :
    PROFILE: As inflammatory bowel disease grows in global incidence, Dr Jon Florholmen outlines what could help to create a cure
    PAN european networks science and technology 2014
  • Turid, Inger, Jan-Olof, Vivian, Ruth H, Kristian et al.:
    The Impact of Ionizing Radiation on the Motility and Matrix Remodelling Properties of Carcinoma-associated Fibroblasts
    European Journal of Cancer 2011
  • Vasilis, Christopher Graham, Ruth H, Åse, Ganesh :
    Global gene expression profiling in the first and third trimesters of normal human pregnancy
    Placenta 2011
  • Vasilis, Christopher Graham, Ruth H, Åse, Ganesh :
    GLOBAL PLACENTAL GENE EXPRESSION PROFILING IN THE FIRST AND THIRD TRIMESTERS OF NORMAL HUMAN PREGNANCY
    Placenta 2011
  • Kristin, Christopher Graham, J, Jørn, Endre, Ruth H :
    New specific molecular targets for radiochemotherapy in colorectal cancer
    The FEBS Journal 2009
  • Karina Standahl, CG, Endre, Livar, RH, E :
    Associations between serum linolenic acid/alpha-linolenic acid ratio and blood gene expression profiles
    The FEBS Journal 2009
  • trine, Margareth Bergesen, Ruth H, Kirsti :
    Increased gene expression diversity between female and male hearts after transverse aortic constriction (TAC)
    European Journal of Heart Failure. Supplements 2009
  • trine, Margareth Bergesen, Ruth H, Kirsti :
    Increased gene expression diversity between female and male hearts after transverse aortic constriction (TAC)
    2009
  • trine, Margareth Bergesen, Ruth H, Kirsti :
    Increased gene expression diversity between female and male mice hearts after transverse aortic constriction (TAC)
    2009

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    Publikasjoner utenom Cristin

    R.H. Paulssen, E.J. Paulssen, J.O. Gordeladze and K.M. Gautvik: THE ELUCIDATION OF RECEPTOR-EFFECTOR COUPLING IN RAT PITUITARY (GH3) CELLS BY THE USE OF ANTISENSE TECHNIQUES. J.Cell.Biochem. (1991) Suppl. 15D:26.

    G. Jablonski, B.M. Mortensen, R.H. Paulssen, H.W. Lund and J.O. Gordeladze: THE EFFECT OF UREMIA AND ALUMINIUM INTOXICATION ON HORMONE SIGNALING IN THE OSTEOBLAST. J. Bone Miner. Res. (1992), 7 Suppl. 1:225.

    R.H. Paulssen, N. Fraeyman and J. Florholmen: ACTIVATION OF PHOPHOLIPASE C BY CHOLECYSTOKININ IN INSULIN (b-TC3)-, SOMATOSTATIN (Rin1027-B2)- AND GLUCAGON (INR1-G9)- SECRETING PANCREATIC CELL LINES: IDENTIFICATION OF DIFFERENT CCK-RECEPTOR SUBTYPES AND G PROTEIN-COUPLING SPECIFICITIES. FASEB J. (1997), 11 Suppl. 9: 2767.

    N.V. Ermakova, R.H. Paulssen and J. Florholmen: THE EFFECT OF TNF-a ON CELL GROWTH AND PLC-g EXPRESSION IN INSULIN-SECRETING b-CELLS. Diabetologia (1999), 42:529.

     J.B. Hansen, B. Svensson, B. Østerud, R. Olsen, M. Ezban and R.H. Paulssen: HEPARIN INDUCES SYNTHESIS AND SECRETION OF TISSUE FACTOR PATHWAY INHIBITOR (TFPI) FROM ENDOTHELIAL CELLS IN VITRO. Thromb. Haemostasis (1999), Suppl. 92.

    N.V. Evgenov, R.H. Paulssen, O.V. Evgenov, I. Christiansen and J. Florholmen: TUMOR NECROSIS FACTOR-a INDUCES APOPTOSIS IN AN INSULIN-SECRETING b-CELL LINE. Diabetes Res.Clin.Practice (2000), 50:S150.

    R. H. Paulssen, J. Sørli, N.V. Evgenov and S. Krum-Hansen: REGULATION AND EXPRESSION OF PROTEIN KINASE C ISOFORMS BY CHOLECYSTOKININ AND GASTRIN IN A SOMATOSTATIN-SECRETING PANCRETIC Rin1027-B2 CELL LINE. Eur.J.Biochem (2001), 268, Suppl. 1:103.

    N. Fraeyman and R. Paulssen: CENTRAL ROLE OF PKCa IN THE DESENSITISATION OF M3-MUSCARINIC RECEPTORS. Eur.J.Biochem. (2001), 268, Suppl. 1: 92.

    L. Thommesen, E. Hofsli, R.H. Paulssen, M.W. Anthonsen, and A. Lægreid: MOLECULAR MECHANISMS INVOLVED IN GASTRIN MEDIATED REGULATION OF cAMP-RESPONSIVE (CRE) PROMOTOR ELEMENT. Am.J.Physiol. – Endocrinol. And Metab. APStracts (2001), 8:0201E.

    E. Mortensen, L. Hansen, N. Bjurstam, S. Klenow, J.O. Frantzen and R.H. Paulssen: IMPRINT OF CORE BIOPSIES AS A RELIABLE DIAGNOSTIC TOOL IN BREAST CANCER AND POSSIBLE USEFULNESS FOR RESEARCH PURPOSES. Breast Cancer Res. (2005), 7, Suppl.  2:33.

    R.H. Paulssen, L. Olsen, and T.C. Sogn: MagNA PURE COMPACT RNA ISOLATION KIT: ISOLATION OG HIGH-QUALITY TOTAL RNA SAMPLES FROM A BROAD RANGE OF SAMPLE MATERIAL. Biochemica (2006), 2:14-16.

    V. Sitras, R.H. Paulssen, H. Grønaas, and G. Acharya: GENE EXPRESSION PROFILE IN LABORING AND NON-LABORING PLACENTA NEAR TERM.  Am. J. Obst. Gynecol. (2007), 195, Suppl. S197.

    V. Dumeaux, K.S. Olsen, J. Leirvik, R.H. Paulssen, A.L. Borresen-Dale, and E. Lund: VARIATION OF GENE EXPRESSION PROFILES IN WHOLE BLOOD FROM A LARGE REPRESENTATIVE SAMPLE OF POSTMENOPAUSAL NORWEGIAN WOMEN. Eur. J. Cancer (2008), 6, Suppl. 9:97.

    K.S. Olsen, C.G. Fenton, E. Anderssen, L. Frøyland, R.H. Paulssen, and E. Lund: ASSOCIATIONS BETWEEN SERUM LINOLENIC ACID/ALPHA-LINOLENIC ACID RATIO AND BLOOD GENE EXPRESSION PROFILES, FEBS J. (2009), 276, Suppl. 1:115-116.

    K. Snipstad, C.G. Fenton, J. Kjæve, E. Anderssen and R.H. Paulssen: NEW SPECIFIC MOLECULAR TARGETS FOR RADIOCHEMOTHERAPY IN COLORECTAL CANCER, FEBS J. (2009), 276, Suppl. 1:121.

    T. Lund, M.B. Hals, R.H. Paulssen, and K. Ytrehus: INCREASED GENE EXPRESSION DIVERSITY BETWEEN FEMALE AND MALE MICE HEARTS AFTER TRANSVERSE AORTIC CONTRICTION (TAC). Eur. J. Heart Failure Supplements (2009), 8 (2).

    K.S. Olsen, C. Fenton, E. Anderssen, L. Frøyland, R.H. Paulssen, V. Dumeaux, and E. Lund: EEFECTS OF PLASMA FATTY ACID RATIOS ON THE BLOOD TRANSCRIPTOME. Norwegian Journal of Epidemiology (2009), 19: Suppl. 1:9.

    V. Sitras, C. Fenton, R.H. Paulssen, A. Vårtun and G. Acharya: GLOBAL PLACENTAL GENE EXPRESSION PROFILING IN THE FIRST AND THIRD TRIMESTERS OF NORMAL HUMAN PREGNANCY. Placenta (2011), 32: A136, P2.117.

    Electro Cell Manipulator Ô, ECMâ600 Electroporation Protocol 0055, BTX Dicision of  GenetronicsÓ (BTX ID #1130).

    Compendium to User Course  “Introduction to Microarray Technology and Data Analysis” (Annual Issues 2004 -2010).

     FEBS News, Issue 5, September 2008, p. 11.

     FEBS News, Issue 5, October 2009, p. 8-9.

     FEBS News, Issue 4, October 2010, p. 8.

    Compendium to User Course “Introduction to High-Throughput Genomics and Data Analysis” (2012).

     

    CV

    Name:                        Ruth Hracky Paulssen

    Date of Birth:            30.08.57

    Nationality:              German/Norwegian

    Marital status:         Married, two children

    Education

    1986:               Diploma in Biochemistry at University of Hannover, Germany. Diploma work at the Botanical Institute, Ludwig-Maximillians University Munich, Germany. Title: «Phosphorylation/Dephosphorylation in the Cytosolof Pea Mesophyll cells».

    1992:               Ph.D., University of Oslo. Thesis title: «G protein-coupled Transmembrane Signalling in Prolactin-Producing rat Pituitary Tumour Cells».

     Appointments

    1981 – 1984:   Research Assistant at the Institute of Clinical Chemistry, Veterinary University Hannover, Germany.

    1985 – 1987:   Student Fellow, Botanical Institute, Ludwig-Maximillians University Munich, Germany.

    1986:             Research Assistant, Botanical Institute, Ludwig-Maximillians University Munich, Germany.

    1988:              Bioengineer, Institute of Medical Biochemistry, University of Oslo, Norway.

    1989-1993:     Ph.D. Student (The Norwegian Cancer Society Fellowship), Institute of Medical Biochemistry, University of Oslo, Norway.

    1993-1995:     Post doctoral Fellow (The Human Frontier Science Program Organization, HFSPO Long-term Fellowship), Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, USA.

    1996-1998:     Research Scientist, Institute of Clinical Medicine, University of Tromsø, Norway.

    1999-2004      Associate professor, Institute of Clinical Medicine, Laboratory of Molecular Medical Research, University of Tromsø and University Hospital of North Norway (UNN), Tromsø, Norway.

    Since 2005      Professor, Department of Clinical Medicine, University of Tromsø, Tromsø, Norway.

     

     

    MH øst L9.143C


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