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Bilde av Larsen, Atle Noralf
Bilde av Larsen, Atle Noralf
Institutt for kjemi atle.larsen@uit.no +4777644478 Tromsø You can find me here

Atle Noralf Larsen

  • Yvonne, Man Kumari, Atle Noralf :
    Characterization and engineering of a DNA polymerase reveals a single amino-acid substitution in the fingers subdomain to increase strand-displacement activity of A-family prokaryotic DNA polymerases
    BMC Molecular and Cell Biology 2019 DOI / ARKIV
  • Yvonne, Kristel, David P., Ingar, Atle Noralf :
    Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity
    FEBS Open Bio 2019 DOI / ARKIV
  • Natasha, Clemens, Børge Nilsen, Tori, Jarl, Atle Noralf et al.:
    Immune response of Atlantic salmon to recombinant flagellin
    Vaccine 2011 DOI
  • Makoto, Stein Tore, Trond Ø., Atle Noralf :
    Characterization of an antiserum against Atlantic cod (Gadus morhua L.) g-type lysozyme
    Fish and Shellfish Immunology 2010 DOI
  • Ronny, Renate Lie, Solrun, Peter, Atle Noralf :
    Crystal structures of g-type lysozyme from Atlantic cod shed new light on substrate binding and the catalytic mechanism
    Cellular and Molecular Life Sciences (CMLS) 2009 DOI
  • Jaya, Atle Noralf, Jarl, Roy Ambli :
    Interleukin-17D in Atlantic salmon (Salmo salar): Molecular characterization, 3D modelling and promoter analysis
    Fish and Shellfish Immunology 2009 DOI
  • Atle Noralf, Terese, Gunbjørg, Marit, Trond Ø. :
    Molecular characterisation of a goose-type lysozyme gene in Atlantic cod (Gadus morhua L.)
    Fish and Shellfish Immunology 2009 DOI
  • Terese, Atle Noralf, Marit, Trond Ø. :
    Identification, cloning and expression analysis of a hepcidin cDNA of the Atlantic cod (Gadus morhua L.)
    Fish and Shellfish Immunology 2008 DOI
  • Marit, Atle Noralf, Kari, Børre, Ingvill :
    Characterisation and expression analysis of the interleukin genes, IL-1 beta, IL-8 and IL-10, in Atlantic cod (Gadus morhua L.)
    Molecular Immunology 2008 DOI
  • Ronny, Atle Noralf, Arne Oskar, Nils Peder :
    The 1.8 angstrom crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species
    The FEBS Journal 2006
  • Atle Noralf, Elin, Ronny, Dag Rune, Nils Peder :
    Characterization of a recombinantly expressed proteinase K-like enzyme from a psychrotrophic Serratia sp
    The FEBS Journal 2006
  • Yvonne, Netsanet Gizaw, Ronny, Kirsti Merete, Nils Peder, Atle Noralf :
    Enzymes from the Arctic - The cold gold
    2015
  • Yvonne, Netsanet Gizaw, Ronny, Kirsti Merete, Bjarne, Arne O. et al.:
    Enzymes from the Arctic - The cold gold
    2014
  • Yvonne, Kirsti Merete, Netsanet Gizaw, Bjarne, Arne O., Trond Ø. et al.:
    MabCent - Discovery of arctic marine enzymes
    2012
  • Atle Noralf, Laila, Kirsti Merete, Solrun, Trond Ø., Nils Peder :
    MabCent - Hunting for Enzymes in the cold North
    2009
  • Roy Ambli, jan-eirik, Merete Bjørgan, Atle Noralf :
    Vil løse fiskesykdomsgåten
    26. mars 2008
  • Makoto, Atle Noralf, jan, Merete Bjørgan, Kiron :
    A preliminary study on the intestinal immune system of Atlantic cod (Gadus morhua L.)
    2007
  • Atle Noralf :
    CodImm- Defence genes and immune mechanisms against viral and bacterial diseases of Atlantic cod
    2007
  • Atle Noralf, Ronny, Gunbjørg, Trond Ø. :
    Identification, cloning and recombinant expression of a goose-type lysozyme from Atlantic cod (Gadus Morhua)
    2007
  • Ronny, Atle Noralf, Nils Peder :
    Structural basis for substrate specificity in two enzymes in the Proteinase K family
    2005
  • Atle Noralf, Ronny, Dag Rune, Nils Peder :
    Structural basis for S1-S4 specificity in two enzymes of the proteinase K family
    2004

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    Publikasjoner utenom Cristin

    Commercially available enzyme products from our research:

    Heat-labile exonuclease I: https://arcticzymes.com/technology/hl-exol/

    DNA polymerase – Isopol™ : https://arcticzymes.com/technology/isopol-dna-polymerase/

    DNA polymerase - Isopol™ SD+: https://arcticzymes.com/technology/isopol-sd/

    DNA polymerase - IsoPol™ BST+: https://arcticzymes.com/technology/isopol-bst/

     

    Patents:

    Larsen A.N., Piotrowski Y., “Position based increase in application relevant properties”. Patent application filed in UK December 2017

    Larsen A.N., Piotrowski Y., Assefa N.G., Lanes O. ”Marine DNA polymerase”. Patent application filed in UK March 2016, Patent Application No. 1604876.1

    Larsen A.N., Piotrowski Y., Willassen N.P., Lanes O., Lorentzen M.S., Solstad T., Andreassen E., Elde M. ”Heat Labile Exonucleases” International Patent Application, PCT/EP2015/001703

    Research interests

    My research interest is to characterise and develop enzymes originating from the arctic marine environment for use in molecular biology and diagnostic applications as well as RNA therapeutics. I have a particular research focus on nucleases and polymerases.


    Member of research group

    Biological Chemistry and Bioinformatics   English content

    Member of project

    Enzyme Discovery and Design    English content
    Forskningsparken 3 G219


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