Photo: Christian Halvorsen
Terje Johansen
Job description
Professor i Biokjemi og Cellebiologi med mekanistisk grunnforskning innen selektiv autofagi som hovedforskningsfelt.
Forskningsgruppeleder for Autophagy Research Group (Autofagiforskningsgruppa).
Vitenskapelig leder for Proteomikk og Metabolomikk kjernefasiliteten (PRiME) ved UiT.
Maria Dravecka,
Ingvild Mikkola,
Terje Johansen,
Ole Morten Seternes,
Jakob Mejlvang
:
Low extracellular pH protects cancer cells from ammonia toxicity
Cell death discovery 2025 DOI
Yakubu Princely Abudu,
Athanasios Kournoutis,
Hanne Britt Brenne,
Trond Lamark,
Terje Johansen
:
MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
Athanasios Kournoutis,
Trond Lamark,
Terje Johansen,
Yakubu Princely Abudu
:
WDR83/MORG1 inhibits RRAG GTPase-MTORC1 signaling to facilitate basal autophagy
Athanasios Kournoutis,
Terje Johansen
:
LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
Hallvard Lauritz Olsvik,
Terje Johansen
:
AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research
Viola Nahse-Kumpf,
Camilla Raiborg,
Kia Wee Tan,
Sissel Mørk,
Maria Lyngaas Torgersen,
Eva Wenzel
et al.:
ATPase activity of DFCP1 controls selective autophagy
Jianwen Zhou,
Nikoline Lander Rasmussen,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
Vladimir V. Rogov,
Ioannis P. Nezis,
P Tsapras,
Hong Zhang,
Yasin Dagdas,
Nobuo N Noda
et al.:
Atg8 family proteins, LIR/AIM motifs and other interaction modes
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Stéphanie Kaeser-Pebernard,
Trond Lamark,
Joern Dengjel
et al.:
The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR
Jingyue Jia,
Fulong Wang,
Zambarlal Babanrao Bhujabal,
Ryan Peters,
Michal Mudd,
Thabata Duque
et al.:
Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage
Jingyue Jia,
Fulong Wang,
Zambarlal Babanrao Bhujabal,
Ryan Peters,
Michal Mudd,
Thabata Duque
et al.:
Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage
Nikoline Lander Rasmussen,
Athanasios Kournoutis,
Trond Lamark,
Terje Johansen
:
NBR1: The archetypal selective autophagy receptor
Juncal Garcia Garcia,
Anne Kristin McLaren Berge,
Katrine Stange Overå,
Kenneth Bowitz Larsen,
Zambarlal Babanrao Bhujabal,
Andreas Brech
et al.:
TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1
Thaddaeus Mutugi Nthiga,
Birendra Kumar Shrestha,
Jack-Ansgar Bruun,
Kenneth Bowitz Larsen,
Trond Lamark,
Terje Johansen
:
Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy
Yakubu Princely Abudu,
Birendra Kumar Shrestha,
Wenxin Zhang,
Anthimi Palara,
Hanne Britt Brenne,
Kenneth Bowitz Larsen
et al.:
SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components
Martina Wirth,
Stephane Mouilleron,
Wenxin Zhang,
Eva Sjøttem,
Yakubu Princely Abudu,
Ashish Jain
et al.:
Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity
Yahyah Aman,
Tomas Schmauck-Medina,
Malene Hansen,
Richard I. Morimoto,
Anna Katharina Simon,
Ivana Bjedov
et al.:
Autophagy in healthy aging and disease
Nature Aging 2021 DOI
Thaddaeus Mutugi Nthiga,
Birendra Kumar Shrestha,
Trond Lamark,
Terje Johansen
:
The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor.
Aurore Claude-Taupin,
Jingyue Jia,
Zambarlal Bhujabal,
Meriem Garfa-Traore,
Suresh Kumar,
Gustavo Peixoto Duarte da Silva
et al.:
ATG9A protects the plasma membrane from programmed and incidental permeabilization.
Daniel J. Klionsky,
Giulia Petroni,
Ravi K Amaravadi,
Eric H Baehrecke,
Andrea Ballabio,
Patricia Boya
et al.:
Autophagy in major human diseases
Trond Lamark,
Terje Johansen
:
Mechanisms of Selective Autophagy
Daniel J. Klionsky,
Amal Kamal Abdel-Aziz,
Sara Abdelfatah,
Mahmoud Khaled Abdellatif,
Asghar Abdoli,
Yakubu Princely Abudu
et al.:
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Autophagy 2021 DOI
Yakubu Princely Abudu,
Stephane Mouilleron,
Sharon A Tooze,
Trond Lamark,
Terje Johansen
:
SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy
Thaddaeu Mutugi Nthiga,
Birendra Kumar Shrestha,
Trond Lamark,
Terje Johansen
:
CALCOCO1 is a soluble reticulophagy receptor
S. Petridi,
A.-C. Jacomin,
Zambarlal Bhujabal,
Terje Johansen,
Ioannis P Nezis
:
Exploring selective autophagy in Drosophila: Methods to identify Atg8-interacting proteins.
Methods in Cell Biology 2020 DOI
Åsa birna Birgisdottir,
Terje Johansen
:
Autophagy and endocytosis – interconnections and interdependencies
Arjen J. Jakobi,
Stefan T. Huber,
Simon A. Mortensen,
Sebastian Schultz,
Anthimi Palara,
Tanja Kuhm
et al.:
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
Thaddaeus Mutugi Nthiga,
Birendra Kumar Shrestha,
Eva Sjøttem,
Trond Lamark,
Terje Johansen
:
CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy
Rocío de la Riva-Carrasco,
Sebastián Perez-Pandolfo,
Sofía Suárez Freire,
Nuria M. Romero,
Zambarlal Bhujabal,
Terje Johansen
et al.:
The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues
Caiyue Xu,
Lu Wang,
Parinaz Fozouni,
Gry Evjen,
Vemika Chandra,
Jing Jiang
et al.:
SIRT1 is downregulated by autophagy in senescence and ageing
Lu Wang,
Caiyue Xu,
Terje Johansen,
Shelley L. Berger,
Zhixun Dou
:
SIRT1 - a new mammalian substrate of nuclear autophagy
Anne-Claire Jacomin,
Raksha Gohel,
Zunoon Hussain,
Agnes Varga,
Tamas Maruzs,
Mark Eddison
et al.:
Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila
Anne-Claire Jacomin,
Stavroula Petridi,
Marisa Di Monaco,
Zambarlal Bhujabal,
Ashish Jain,
Nitha C. Mulakkal
et al.:
Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila
Stephanie R Kehl,
Brandy-Lee A Soos,
Bhaskar Saha,
Seong Won Choi,
Anthony W Herren,
Terje Johansen
et al.:
TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform
Petri Pölonen,
Ashik Jawahar Deen,
Hanna M. Leinonen,
Henna-Kaisa Jyrkkänen,
Suvi Kuosmanen,
Mimmi Mononen
et al.:
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Åsa birna Birgisdottir,
Stephane Mouilleron,
Zambarlal Bhujabal,
Martina Wirth,
Eva Sjøttem,
Gry Evjen
et al.:
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
Suresh Kumar,
Yuexi Gu,
Yakubu Princely Abudu,
Jack-Ansgar Bruun,
Ashish Jain,
Farzin Farzam
et al.:
Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation
Yakubu Princely Abudu,
Serhiy Pankiv,
Benan John Mathai,
Alf Håkon Lystad,
Christian Bindesbøll,
Hanne Britt Brenne
et al.:
NIPSNAP1 and NIPSNAP2 act as “eat-me signal” for mitophagy
Aurélien Schwob,
Elodie Teruel,
Louise Dubuisson,
Florence Lormières,
Pauline Verlhac,
Yakubu Princely Abudu
et al.:
SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function
Martina Wirth,
Wenxin Zhang,
Minoo Razi,
Lynet Nyoni,
Dhira Joshi,
Nicola O'Reilly
et al.:
Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins
Katrine Stange Overå,
Juncal Garcia Garcia,
Zambarlal Bhujabal,
Ashish Jain,
Aud Karin Øvervatn,
Kenneth Bowitz Larsen
et al.:
TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1
Terje Johansen
:
Selective Autophagy: RNA Comes from the Vault to Regulate p62/SQSTM1
Birendra Kumar Shrestha,
Mads Skytte Rasmussen,
Yakubu Princely Abudu,
Jack-Ansgar Bruun,
Kenneth Bowitz Larsen,
Endalkachew Ashenafi Alemu
et al.:
NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1
Terje Johansen,
Trond Lamark
:
Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors
Terje Johansen
:
Selektiv autofagi: Kildesortering i cellene våre gir sunn aldring
2022
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
2021
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
2021
Nikoline Lander Rasmussen,
Jianwen Zhou,
Hallvard Lauritz Olsvik,
Vyacheslav Akimov,
Zehan Hu,
Gry Evjen
et al.:
TNIP1 is degraded by selective autophagy upon proinflammatory signalling
2021
Martina Wirth,
Stephane Mouilleron,
Wenxin Zhang,
Eva Sjøttem,
Yakubu Princely Abudu,
Ashish Jain
et al.:
Corrigendum to Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity (Journal of Molecular Biology (2021) 433(13), (S0022283621001881), (10.1016/j.jmb.2021.166987))
Journal of Molecular Biology (JMB) 2021 DOI
Sebastian Andres Acuña Maldonado,
Ida Sundvor Opstad,
Luis Enrique Villegas Hernandez,
Mona Nystad,
Milton O Aguilera,
Merete Storflor
et al.:
Fluorescence Nanoscopy Using Multiple Signal Classiflcation
Algorithm (MUSICAL): From Electromagnetics Inverse
Scattering Problem to Optics Inverse Source Problem
2019
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Research interests
Autofagi, celle signalering og genregulering med relevans for kreft,nevrodegenererende sykdommer og forsvar mot intracellulære infeksjoner.
Teaching
Forelesninger på kurs i:
MBI-2001 Biokjemi - 10 STP
MBI-2012 Molekylær Cellebiology – Cellestruktur - 10 STP
MBI-3004 The Biology of Cancer - 10 STP
MBI-3012 Advanced methods in experimental biomedicine - 30 STP
MBI-8007 Molecular and Clinical Aspects of Cancer - Block I - 10 STP