Disputas- Cand. med. Torstein Lindahl Schanche

Avhandlingen er tilgjengelig her. The doctoral thesis.  Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted:   “Thermoregulation in the ICU: Pathophysiology, Monitoring, and Clinical Relevance”. Prøveforelesningen vil også bli strømmet/the trail lecture will also be streamed. Disputasen starter kl. 1215. Disputasen vil bli strømmet her. Opptak av disputasen vil være tilgjengelig i et døgn. The defense will be streamed here. A recording of the disputation will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:
Accidental hypothermia is a rare and dangerous condition, it can cause derangements of cardiovascular function including cardiac arrest and effects of medications may change. Performing controlled studies in humans is challenging and scientific evidence to guide treatment is lacking. Therefore, we performed studies in animal models aiming to increase knowledge and improve outcome.

We cooled rats and pigs to cardiac arrest and rewarmed them with a heart-lung machine. In rats, we tested different fluid types and found that one of them improved blood flow and caused less edema. After 3 hours of cardiopulmonary resuscitation in pigs, the heart-lung machine restored blood flow to vital organs.

Rats with maintained spontaneous cardiac function were rewarmed from 15°C and were treated with intravenous fluids to maintain normal blood volume, this led to improved cardiac function compared to untreated rats.

Cardiac cells cooled to 15°C and rewarmed to 37°C showed reduced contractile function, which was not improved after treatment with epinephrine.

Hovedveileder
Professor emeritus Torkjel Tveita, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet

Biveileder
Professor Gary  C. Sieck, Department of Physiology and Biomedical Engineering, Mayo Clinic, MN, USA.  

Bedømmelseskomité
Professor Sten Rubertsson, Uppsala University Hospital - 1. opponent.
Professor Theresa Mariero Olasveengen, Oslo universitetsykehus - 2. opponent.
Førsteamanuensis Ole Magnus Filseth, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet - leder av komité.

Disputasleder: Professor Johan Gustav Bellika, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.