Disputas- Master i biomedisin Christabel Esi Damoah

Avhandlingen er tilgjengelig her! The doctoral thesis! Prøveforelesning over oppgitt emne holdes kl. 09.15, samme sted: Hereditary angioedema: a rare hereditary disorder involving both the complement system and the coagulation system. Prøveforelesningen vil også bli strømmet her/the trial lecture will be streamed. Disputasen starter kl. 1115. Auditoriet er åpent for publikum, men disputasen vil også bli strømmet her.  Opptak av disputasen vil være tilgjengelig i et døgn. The auditorium is open to the public. The defense will still be streamed here.  A recording of the disputation will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:

Venous thromboembolism (VTE) is a common and fatal disease with substantial burden to society. Cumulative evidence suggests a role of the complement system, specifically the lectin pathway (LP), in the pathogenesis of VTE; however, the underlying mechanisms remain elusive. In this thesis, we have investigated the association of mannose-binding lectin (MBL) and mannose-binding lectin -associated serine protease-2 (MASP-2), key components of the lectin pathway, in relation to VTE by using data from the Nord-Trøndelag Health (HUNT) Study and the Tromsø Study respectively.
We found that high plasma levels of MBL and MASP-2 were associated with increased risk of VTE. Genetic analysis revealed a causal role of MBL and MASP-2 on VTE risk. Further functional analysis indicated that MBL-MASP complexes could trigger thrombin generation, a key component of blood clotting process. Our findings suggest that MBL and MASP-2 are potential risk biomarkers for VTE and molecular targets for prevention of VTE.

Hovedveileder
Professor John Bjarne Hansen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Bedømmelseskomité
Professor Bengt Zöller, Center for Primary Health Care Research, SUS Malmö University Hospital, Malmö, Sweden – 1. Opponent.
Assoc. Professor (Docent) Maria Bruzelius, Karolinska Institutet och Karolinska University Hospital, Stockholm, Sweden – 2. opponent.
Professor emeritus Rolf Jorde, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder: Professor Heidi Tiller, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.